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> Stent Coating Machine > Yukon DES > Yukon Plus > Curare Cathy No 3
MThe Stent Coating Machine
> Product Overview > The Concept > Features > Handling
TRANSLUMINA COATING TECHNIQUE AND POLYMER ISSUES

Several publications report about the possibility of using a polymer as a good solution to store the drug and to define a release mechanism. On the other hand, there are many publications that rise concerns about the usage of polymers as biocompatible implant materials. Polymers can create severe inflammatory reactions, sometimes immediately after implantation, sometimes after several months or years, due to the oxidative decomposition of the polymer matrices by human macrophages or active enzymatic reactions.
(see literature Van der Giesson et al, Circulation 1996, 94, 1690-1697 and A.Curcio et al., Am.J.Physiol. Heart Circ. Physiol. (2003), in press, online available.)

The most important factor for the efficiency of the drug is the effect of the drug itself and the possibility of transporting the drug to the vessel wall without any disturbances. With a polymer there are several essential disadvantages:
  1. Decreased biocompatibility at least over a long time (inflammation).
  2. Decreased release due to the bonding effects between the substance and the polymer, especially when using an additional top or covering layer. (see Presentation TCT2003 by M. E. Russel, MD Natick MS "The BSC Drug- Eluting Stent System: Polymer Characteristics and Drug Delivery")
  3. Decreased efficiency of the substance due to long storage periods, especially for sensitive substances.
  4. Thick coating layers with the risk of loosing coating layer plaques and the risk of embolism due to a high polymer/substance ratio (e.g. 70 % for current competitors stents).
  5. The properties of the coating layer can change after the crimping process. Additionally, very sensitive handling is requested due to the risk that the thick coating layer can be damaged during the intervention or during the postdilatation with another balloon with larger diameter.
  6. Regarding the sensitiveness of the polymer and the type of the lesion, it is noticed that in the clinical routine, physicians sometimes have to perform pre- dilatation to avoid damaging of the polymer coating by calcificated lesions. This is not necessary for implantation of YUKONŽDES Coronary Stent System - PEARL surface.
  7. Due to mechanical characteristics of YUKONŽDES Coronary Stent System - PEARL surface, the flexibility of the stent remains unchanged, compared to lower flexibility of polymer coated stent.
Links to
British Cardiovascular Intervention Society
The Vascular Society
The BCIA

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