|The Stent Coating Machine
THE NUMBER OF DRUGS AVAILABLE IS STILL
LIMITED (SIROLIMUS; PACLITAXEL) – although many other
drugs have been successfully tested, time-to-market is very
long, which is a serious barrier
to introducing new drugs in clinical use.
FOR THE FIRST TIME THERE IS A POSSIBILITY OF A FREE CHOICE
OF DRUG AT THE TIME OF IMPLANTATION - That means that the
treatment can be adapted to the individual patient and
the drug can be
chosen according to the individual needs.
Sirolimus and Taxol both are very aggressive cytostatic
drugs and might not be suitable for all types of lesions.
might offer the possibility to choose less aggressive
drugs for less complex lesions and vice versa. This might
for different very complex patient cohorts such as diabetic
patients and patients on dialysis, in whom still a lot
of research is
needed. Latest publications have shown that e.g. insulin – dependent
diabetics seem not to respond to Sirolimus as well as
other patients. By the use of the machine intense research
field is possible
and reaction to latest scientific findings can be performed.
Nevertheless Sirolimus remains a possibility to be used
with the Translumina technology but can be dosed according
UP TO NOW RESULTS HAVE BEEN INFLUENCED
BY MORE THAN ONE FACTOR – AS
THE RESTENOSIS QUALITIES OF THE STENT PLATFORM AS WELL
AS OF THE DRUG WERE INFLUENCING THE FINAL RESULT. In the
translumina system the delivery platform is always
the same (YUKON DES), and the pure effect of different drugs
They can therefore for the first time be compared without
bias. After going a little bit more into detail about
the complex issue
of polymers and topcoatings the fact that the drug
is offered in its pure form without polymer is of an advantage.
The top coating is not necessary, as it serves primarily
THE COATING PROCESS ITSELF TAKES ONLY
3 – 7 MINUTES
AND GIVES NO DELAY IN THE CLINICAL ROUTINE. CAN BE
PERFORMED BY NURSE OR AN ASISSTANT COLLEAGUE.
PRICE - as the drug is supplied by the
hospital itself, Translumina as a company is not obliged
to price negotiations
with the different
drug companies and can therefore offer a quite substantial
price benefit when compared to other stent companies.
STORAGE IS NOT AN ISSUE - whereas the “conventional” DES
systems can only be stored between 3 – 6 months, the Translumina
stent platform can be stored for up to 2 years without expiring.
Although of course the patient’s benefit is always
the main goal, this side aspect becomes more and more
important.7. FUTURE OUTLOOK: Human growth factors and
different uses of
therapy have also been a hot topic in Cardiology for
the last years. This machine offers possibly the first
these factors on a stent. In the conventional approach
sterilization of the stent has to be performed after
application of the
drug/organic material. Therefore these highly sensible
factors would be destroyed
by the sterilization process. By the use of the machine
everything, be it cells, growth factors etc. can be
applied to the stent
surface, as no conservation or sterilization is needed